NBCNS 2nd research meeting at Solbacka Conference Center Sep 18-19, 2008
The following 50 abstracts were submitted.
A novel celecoxib derivate, OSU03012, suppress medulloblastoma growth by inhibiting ß-Catenin function and MYC expression
Ninib Baryawno1, Baldur Sveinbjörnsson1, 2, Staffan Eksborg1, Per Kogner1* and John Inge Johnsen1.
1Karolinska Institutet, Childhood Cancer Research Unit, Department of Woman & Child Health, S-171 76, Stockholm, Sweden, 2University of Tromsö, Department of Cell Biology and Histology, IMB, Breivika, N-9037, Tromsö, Norway.
Long-term health, functional disability, and follow-up needs of patients and families: Evidence from national childhood CNS-tumour survivor cohort studies
KK Boman1, A Hjern2, F Lindblad3, G Gustafsson1, B Lannering4, E Hovén1, M Anclair1
1 Childhood Caner Research Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm 2 Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden 3 Department of Stress Research, Stockholm University, Stockholm 4 Department of Pediatrics, University of Gothenburg, Gothenburg
STUDIES ON MALIGNANT EMBRYONIC TUMOURS OF NEURAL ORIGIN; - Heterogeneity in clinical tumour samples; seeking to identify, isolate and characterise therapy-resistant tumour cells.
Cedervall, J1, Jamil, S1, Kogner, P1, Sveinbjörnsson, B1 Kanter-Lewensohn, L2, Cheng, Y3, , Eskandarpour, M2, Ringborg, U2,Hansson, J2, Ährlund-Richter, L1
Departments of 1Woman and Child Health, 2Oncology and Pathology, 3Clinical neuroscience, all at Karolinska Institutet, Stockholm, Sweden.
Simultaneous Multifocal Neuroblastoma and Embryonal Rhabdomyosarcoma in a Patient with Combined Germline TP53 R248W Mutation and Turner Syndrome
Cihan Cetinkaya2, Johan Wadenbäck2, Teresita Diaz de Ståhl2, Fredrik Hedborg1,2
1Dpt of Women´s and Children´s Health, 2Dpt of Genetics and Pathology, Uppsala University, Sweden
Translation of immunotherapy against pediatric malignant brain tumors.
Anna Darabi, Sara Fritzell, Edward Visse and Peter Siesjö
Glioma Immunotherapy group, The Rausing laboratory, BMC D14, Lund, Sweden.
Possibilities for tumour diagnostics with magnetic resonance spectroscopy at Astrid Lindgren Children's Hospital
Lena Douglas1, Daniel Martin2, Mikael Mosskin2, Rose-Marie Claesson3 and Bo Nordell1
1)MR-fysik, Avd för Sjukhusfysik, 2)Neuroröntgen, 3)Barnröntgen, Karolinska Universitetssjukhuset,
Inhibition of COX-2 and NO enhances an IFN-gamma based immunotherapy of N32 rat glioma
S Eberstål, W. Badn, M. Esbjörnsson, A. Darabi, E. Visse and P. Siesjö.
Glioma Immunotherapy group, The Rausing laboratory, BMC D14, Lund, Sweden.
Alternative Splicing of PIK3CD is Common in Aggressive Neuroblastoma.
Susanne Fransson and Katarina Ejeskär
Dept. of Clinical Genetics, University of Gothenburg, Göteborg, Sweden
Myc-pathway activation and stage of neuronal differentiation identify more malignant neuroblastomas independently of clinical stage or risk classification.
Erik Fredlund1, Markus Ringnér2, John M. Maris3, and Sven Påhlman1
From the 1Center for Molecular Pathology, Department of Laboratory Medicine, CREATE Health, Lund University, University Hospital MAS, SE-205 02 Malmö, Sweden. 2Division of Oncology, Department of Clinical Sciences, Lund University, SE-221 85 Lund. 3Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine and Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA.
METRONOMIC CHEMOTHERAPY WITH GMX1777 REGRESSES MYCN-AMPLIFIED NEUROBLASTOMA IN MICE
D. Fuchs1, R. Christofferson1, F. Azarbayjani1
1 Department of Medical Cell Biology; Uppsala Universitet, Uppsala, Sweden
Studies on the presence of human polyomaviruses in childhood brain tumours and neuroblastomas.
Géraldine Giraud1, Stefan Holm2, Bengt Gustavsson2, Abiel Orrego3, Per Kogner2 and Tina Dalianis1,4.
1Dept. of Oncology-Pathology, Karolinska Institutet, Cancer Centrum Karolinska, 2Dept. of Woman and Child Health Karolinska Institutet, Astrid Lindgren Children's Hospital, 3Dept of Oncology-Pathology, Laboratory for Pathology, all at Karolinska University Hospital Solna, Stockholm and 4Dept of Virology, Swedish Institute for Infectious Disease Control, Stockholm.
Omega-3 Docosahexaenoic Acid as a Potential Adjuvant to Conventional Neuroblastoma Therapy
H Gleissman1, M Lindskog1, M Hamberg2, CN Serhan3, F Ponthan4, L Elfman1, JI Johnsen1, P Kogner1
1Childhood Cancer Research Unit, Karolinska Institutet, Stockholm. 2Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm. 3Harvard Medical School, Brigham and Womens Hospital, Boston. 4Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne.
MITOCHONDRIA IN NEUROBLASTOMA CELL'S AS PROMISING THERAPEUTIC TARGETS
V. Gogvadze, E. Norberg and B. Zhivotovsky
Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 STOCKHOLM
CLINICAL GRADE DENDRITIC CELL-BASED IMMUNOTHERAPY AGAINST CANCER
K. Gustafsson,1,2 A. Karlsson-Parra2
1Department of Clinical Neuroscience and Rehabilitation, 2Microbiology and Immunology, Göteborg University, Göteborg
Neuroblastoma Cells Go Neuroendocrine When Put Under Hypoxic Stress
Fredrik Hedborg1,2, Krister Karlsson1, Nurtena Östlin1, Reiner Fischer-Colbrie3, Bengt Sandstedt4 1Dpt of Genetics and Pathology, 2Dpt of Women´s & Children´s Health, Uppsala University, Sweden, 3Dpt of Pharmacology, Innsbruck Medical University, Austria, 4Childhood Cancer Research Unit, Karolinska Institute, Sweden
Transgenic expression of PDGFB in astrocytes and astrocyte precursor cells leads to glioblastoma in a Trp53 null background
Sanna-Maria Hede 1, Inga Hansson 2, 3, Gijs B. Afink 1, 4, Anna Eriksson 1 *, Inga Nazarenko 1 *, Johanna Andrae 1, 5 *, Guillem Genove 5 , Bengt Westermark 2 and Monica Nistér 1, 6
1 Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden 2 Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden 3 Department of Neuroscience, Uppsala University, Uppsala, Sweden 4 Laboratory of Pediatric Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 5 Department of Medical Biochemistry and Biophysics, Matrix Biology, Karolinska Institutet, Stockholm, Sweden
Differential recovery of neural stem cells in the subventricular zone and dentate gyrus after ionizing radiation
Nina AK Hellström1, Thomas Björk-Eriksson2,3, Klas Blomgren1,4 and H. Georg Kuhn1
1Center for Brain Repair and Rehabilitation, Institute for Neuroscience and Physiology, University of Gothenburg; 2 Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden, 3 Department of Radiation Oncology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark; 4 Department of Pediatric Oncology, The Queen Silvia Children's Hospital, Gothenburg.
Intrinsic molecular networks regulating glioma stem cells
Falk Hertwig1, Sebastian Braun1, Federico Colecchia1, Patrik Edén1,2, Carsten Peterson1,2, Ulrike A. Nuber1,3
1 Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden 2 Computational Biology and Biological Physics, Department of Theoretical Physics, Lund University, Lund, Sweden 3 Department of Oncology, Lund University Hospital, Lund, Sweden
The eicosanoid-AKT tango and its relevance to medulloblastoma and neuroblastoma
J. I. Johnsen, B. Sveinbjörnsson, L. Segerström, N. Baryawno, A. Rasmuson, H. Gleissman, L. Elfman, M. Khoshnevis, P. Kogner.
Childhood Cancer Research Unit, Dept. Woman & Child Health, Karolinska Institutet, Stockholm, Sweden.
Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
David T W Jones1, Sylvia Kocialkowski1, Lu L Liu1, Danita M Pearson1, L. Magnus Backlund2, Koichi Ichimura1 & V. Peter Collins1
1Department of Pathology, Division of Molecular Histopathology, Cambridge University, Cambridge CB2 0QQ, UK. 2Department of Oncology-Pathology, Karolinska Hospital, 17176 Stockholm, Sweden
Irradiation-induced loss of microglia in the developing brain
Marie Kalm1, Birgitta Lannering2, Thomas Björk-Eriksson3 and Klas Blomgren1,2*
1. Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Box 432, SE 405 30, Sweden. 2. Department of Pediatric Oncology, The Queen Silvia Children's Hospital, SE 416 85 Göteborg, Sweden 3. Department of Oncology, Sahlgrenska University Hospital, SE 413 45 Göteborg, Sweden.
Dexamethasone transiently reduced the generation of new cells in the rat hippocampus
Niklas Karlsson1, Linnea Stridh1, Thomas Björk-Eriksson2, Christiana Cooper-Kuhn1, Klas Blomgren1, 3
1Center for Brain Repair and Rehabilitation, Institute for Neuroscience and Physiology, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden. 2Department of Oncology, Sahlgrenska University Hospital, Göteborg.3Department of Pediatric Oncology, The Queen Silvia Children's Hospital, Göteborg.
Quantitative analysis of transcripts - in absolute terms or relative to housekeeping genes - in the evaluation of minimal residual diseas ein neuroblastoma
Bertil Kågedal, Catarina Träger, Anita Kullman and Per Kogner
Nuclear Receptor Binding Protein 2 is induced during neural progenitor differentiation and affects cell survival
Larsson J.1), Forsberg M. 1), Brännvall K. 1), Zhang X-Q. 1), Enarsson M. 1, 3), Hedborg F. 2) and Forsberg-Nilsson K. 1)
1) Department of Medical Biochemistry and Microbiology, Uppsala University Biomedical Center, Box 582, 751 23 Uppsala, Sweden. 2) Department of Genetics and Pathology, Uppsala University Rudbeck Laboratory, 751 85 Uppsala, Sweden. 3) Present address: Department of Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, M5G1L7, ON, Canada
Identification and characterization of antagonists to the Myc oncoprotein in childhood tumors with deregulated Myc expression
Lars-Gunnar Larsson, Sara Fahlén, Yingtao Su, Karin Ridderstråle, Per Hydbring, Hamid Sharifi, Susanna Tronnersjö, Camilla Mannich Uggla, Helén Nilsson.
Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Box 280, 171 77 Stockholm.
Coaching parents of brain tumour survivors: A pilot study.
Annika Lindahl Norberg
Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden. Ingrid van't Hooft Neuropediatric Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. and Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden.
Tumor characteristics of neural stem cells
Olle Lindberg, Axel Jansson, Christiana Cooper-Kuhn, H. Georg Kuhn
Center for Brain Repair and Rehabilitation, Institute for Neuroscience and Physiology, University of Gothenburg
MYCN-regulated MicroRNAs in Neuroblastoma
Jakob Lovén1, Nikolay Zinin1, Therese Wahlström1, Igor Adameyko2, Andor Pivarcsi3, Enikö Sonkoly3, Inga Müller1, Martin Corcoran4, Patrik Ernfors2, Ulf Ribacke1 and Marie Henriksson1
1Department of Microbiology, Tumor and Cell Biology, 2Department of Medical Biochemistry and Biophysics, 3Department of Medicine, Center for Molecular Medicine, 4Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, SE-17177 Stockholm, Sweden
Binomial segregation of MYCN-carrying double minutes in neuroblastoma by tethering to centric chromosomes: the role of randomness in oncogene amplification
G. Lundberg1, A.H. Rosengren2, Y. Jin1, U. Håkanson3, H. Stewénius4, Y. Stewénius1, S. Påhlman5 and D. Gisselsson1, 6
1Department of Clinical Genetics, Lund University Hospital, Sweden; 2Department of Clinical Sciences Malmö, Lund University, Sweden; 3The Nanometer Structure Consortium, Division of Solid State Physics, Lund University, Sweden; 4Center for Visualization and Virtual Environments, University of Kentucky, USA; 5Department of Clinical Sciences Malmö, Lund University, Sweden; 6Department of Pathology, Lund University Hospital, Sweden.
HIF-1 induces MXI1 by alternate promoter usage in human neuroblastoma cells
Tobias Löfstedt, Erik Fredlund, Linda Holmquist Mengelbier, Siv Beckman, Sven Påhlman and Håkan Axelson.
From the Division of Molecular Medicine, Department of Laboratory Medicine, Lund University, University Hospital MAS, S-205 02 Malmö, Sweden
Novel therapeutic strategies for treatment of medulloblastoma, involving inhibitors of receptor tyrosinekinase and histone deacetylases.
Anna Maria Marino and Tomas Ekström
The neuroblastoma genome; Studies of genomic alterations using copy number microarray analyzes
Tommy Martinsson+, Helena Carén+, Jennie Erichsen+, Rose-Marie Sjöberg+, Hanna Kryh+, Jonas Abrahamsson#, Per Kogner¤
+Department of Clinical Genetics and #Pediatrics, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, (firstname.lastname@example.org).
Characterization of subventricular neuroprogenitors expressing the mutant PDGF -receptor incapable of PI3-kinase activation
Moshiri A, Ishii Y, Moshiri S, Matsumoto Y, Sasahara M, Funa K
Dept. of Medical Chemistry and Cell Biology, Inst. of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg.
Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain
Andrew S. Naylor1,2, Cecilia Bull1, Marie Nilsson3, Changlian Zhu1, Thomas Björk-Eriksson4, Peter S. Eriksson1, Klas Blomgren1, 5* and H. Georg, Kuhn1*
1Center for Brain Repair and Rehabilitation, Institute for Neuroscience and Physiology, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden. 2Department of Physiology, Faculty of Medicine and Health Science, The University of Auckland, Auckland, New Zealand. 3Institute for Neuroscience and Physiology, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden. 4Department of Oncology, Sahlgrenska University Hospital, Göteborg, Sweden.5Department of Pediatric Oncology, The Queen Silvia Children's Hospital, Göteborg, Sweden. *Equal contribution
Models from experiments - using drug combinations to deduce regulatory networks in cancer cells
Sven Nelander1 , Weiqing Wang1 , Björn Nilsson2 , Qing-Bai She3 , Christine Pratilas 3 , Neal Rosen 3 , Peter Gennemark4 , Chris Sander1
1 Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, USA 2 Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden, current address: Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA 3 Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, USA 4 Mathematical Sciences, University of Gothenburg, SE-412 96 Gothenburg, Sweden
Preserved structural integrity of white matter adjacent to low-grade tumors
Nilsson D1,3, Rutka J T2, Raybaud C R3, Widjaja E3
1Institute of Neuroscience and Physiology, Sahlgrenska Academy at Göteborg University, Sweden. 2Division of Neurosurgery, The Hospital for Sick Children, Toronto, Canada. 3 Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada.
High-resolution 32K array-based comparative genomic hybridization of pediatric medulloblastomas
Helena Nord1, Susan Pfeifer1, Monica Nistér2, Jan P. Dumanski1 and Teresita Díaz de Ståhl1
1Uppsala University, Department of Genetics and Pathology, Rudbeck Laboratory, 751 85 Uppsala 2Karolinska Institutet, Department of Oncology Pathology, 171 76 Stockholm
METRONOMIC SCHEDULING OF IMATINIB ABROGATES CLONOGENICITY OF NEUROBLASTOMA CELLS AND ENHANCES THEIR SUSCEPTIBILITY TO SELECTED CHEMOTHERAPEUTIC DRUGS IN VITRO
Ebba Palmberg1, John Inge Johnsen1, Janna Paulsson2, Malin Wickström3,Arne Östman2, Margareta Edgren2, Per Kogner1, Magnus Lindskog1, 3, 4
1)Childhood Cancer Research Unit, Department of Woman and Child Health and 2)Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden, 3)Division of Clinical Pharmacology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 4)Centre for Clinical Research Dalarna, Falun Hospital, Sweden.
Characterization of arsenic trioxide-induced neuroblastoma cell death
Helen M. Pettersson, Anna Dahlman, Erik Fredlund, Caroline Bergenfelz and Sven Påhlman
Center for Molecular Pathology, Department of Laboratory Medicine, CREATE Health, Lund University, University Hospital MAS, Malmö, Sweden.
Human Cytomegalovirus Microinfection Levels in Glioblastoma Multiforme Are of High Prognostic Value for Patient Survival
Afsar Rahbar, Ph.D, Abiel. Orrego, M.D., Giuseppe. Stragliotto, M.D., Inti. Peredo, M.D., Nina Solberg, M.Sc.,Klas Strååt, M.Sc., Cecilia Söderberg-Naucler, M.D, Ph.D
Department of Medicine, Center for Molecular Medicine, Karolinska Institute (A.R., N.,W, K.S., C.S.-N.) and the Cancer Center (A.O.) and Department of Neurosurgery, Karolinska University Hospital (G.S., I.P), Stockholm, Sweden.
Prostaglandin E2 promotes neuroblastoma cell growth that can be inhibited by specific prostanoid receptor antagonists.
Agnes Rasmuson1, Jaione Simon-SantaMaria2, Mehrnoush Khoshnevis1, Abiel Orrego1, John Inge Johnsen1, Per Kogner1, Baldur Sveinbjörnsson1,2.
1Karolinska Institutet, Stockholm, Sweden 2University of Tromsø, Tromsø, Norway
Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma
Johan Rebetz1, Dongping Tian1, Annette Persson5, Bengt Widegren1,3, Leif G. Salford1, Elisabet Englund5, David Gisselsson4 and Xiaolong Fan1,2
1The Rausing Laboratory, Division of Neurosurgery, Lund University Hospital; 2Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University; 3Department of Cell and Molecular Biology, Lund University; 4Department of Clinical Genetics, Lund University Hospital; 5Department of Pathology, Lund University Hospital; Lund, Sweden.
IDENTIFICATION OF LOW MOLECULAR WEIGHT COMPOUNDS REGULATING MYC
K. Ridderstråle1*, P. Hydbring1,2*, C. Mannich Uggla1, M. Vita1, M. Arsenian Henriksson1 and L-G. Larsson1,2
1Dept. of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, SE-171 77 Stockholm, 2Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden *These authors contributed equally to the work
Immunization with autologous glioma cells transfected with IFN- gene significantly prolongs survival of patients with Glioblastoma Multiforme
Salford LG 1,2*, Siesjö P 1,2*, Skagerberg G 1,2*, Rydelius A 2,3, Blennow C 1,2, Lilja Å 1,4, Persson BRR 2,5, Strömblad S 1,2,Visse E 1,2 and Widegren B 2,6
Dept. of Neurosurgery 1, The Rausing Laboratory 2, Depts of Neurology 3, Psychology 4, Medical Radiation Physics 4 and Tumour Immunology 5 Lund University, Lund, Sweden
The transplantation therapy of neural progenitor cells into the brains of irradiated juvenile mice
Y. SATO1,2, N. SHINJYO3, N. KARLSSON1, K. OSATO1,4, C. ZHU1,5, M. PEKNY1, M. PEKNA3, K. BLOMGREN1,6
1. Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. 2. Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan 3. Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, GothenburgUniversity, 4. Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Kiyotake, Japan. 5. Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China 6. Department of Pediatric Oncology, the Queen Silvia Children's Hospital, Gothenburg, Sweden.
Expression of enzymes and receptors of the leukotrienepathway in human neuroblastomapromotestumorsurvival and provides target for therapy
Baldur Sveinbjörnsson1,2*, Agnes Rasmuson1*, Ninib Baryawno1,Min Wan3, Ingvild Pettersen2, Frida Ponthan1,4, Abiel Orrego5, Jesper Z. Haeggström3, John I. Johnsen1 and Per Kogner1.
1Childhood Cancer Research Unit, Department of Woman and Child Health, KarolinskaInstitutet, Stockholm, Sweden; 2Department of Cell Biology and Histology, Faculty of Medicine, University of Tromsö, Tromsö, Norway; 3Department of Medical Biochemistry and Biophysics; 4Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom and 5Department of Oncology and Pathology, KarolinskaInstitutet, Stockholm, Sweden.
Hes1 and the corepressor CtBP control the decision between BMP-mediated neuronal or non-neural differentiation of dorsal neural stem cells
A. I. Teixeira1, J.M. Dias2, S. Ilkhanizadeh1, J. K. Duckworth1, M. G. Rosenfeld3, J. Ericson2, *O. B. Hermanson1
1Dept Neuroscience, 2CMB, Karolinska Inst. Stockholm Sweden; 3HHMI, Dept. Med., UCSD, La Jolla, CA
MYC as a target for development of novel cancer drugs
Marina Vita, Ami Albihn, Therese Wahlström, and Marie Henriksson.
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S-171 77 Stockholm, Sweden
Dysregulation of PDGF -receptor expression by Np73 in neuroblastoma
Daniel Wetterskog§, Toshinori Ozaki*, Akira Nakagawara*, and Keiko Funa§
From the § Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Göteborg University, Box 420, SE-40530 Gothenburg, Sweden and the * Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan
Characterization of the molecular differentiation of neuroblastic tumors to define targets for therapy of high-risk neuroblastoma patients
I. Øra1, D. Gisselsson2, C. van der Loos3, P. van Sluis4, J. Koster4, R. Versteeg4.
1Dept of Pediatric Oncology, University Hospital Lund, Sweden 2Dept of Pathology / Clinical Genetics, University Hospital Lund, Sweden 3Dept of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands 4Dept of Human Genetics, Academic Medical Center, University of Amsterdam, The Netherlands
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